Cyclohexyl isocyanate → HCID 22478990, compound

HRID 1837576Notes

Reaction equation

HRID 1837576 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:18][CH2:19][CH2:20][NH2:21])[C:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:17]=1)[CH2:2][CH2:3][CH3:4].[CH:22]1([N:28]=[C:29]=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH2:1]([C:5]1[N:6]([CH2:18][CH2:19][CH2:20][NH:21][C:29]([NH:28][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:30])[C:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:17]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 223444213-(2-Butyl-1H-imidazo[4,5-c]quinolin-1-yl)propan-1-amine

Product 1

HCID 22478990HCID 22478990, compoundYield 90.8%

Procedure

Using the general method of Example 146 Part B, 3-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propylamine (2.00 g, 7.08 mmol) was reacted with cyclohexyl isocyanate (1.0 g, 7.98 mmol) to provide 2.62 g of N-[3-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]-N′-cyclohexylurea.

Sources & evidence

ORD record
ord-8451823509f148baa9de27255a03f6c3
Source dataset
uspto-grants-2004_08
Patent number
US06784188B2

Reaction notes

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