4-Morpholinecarbonyl chloride → HCID 10251348, compound

Participants

Reaction Steps

Using the general method of Example 167, 1-(3-aminopropyl)-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-4-amine (2.0 g, 6.59 mmol) was reacted with 4-morpholinecarbonyl chloride (1.08 g, 7.25 mmol) to provide 1.22 g of N-{3-[4-amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-yl]propyl}morpholine-4-carboxamide as a white powder, m.p. 171.8-173.2° C. Analysis: Calculated for C21H32N6O3: %C, 60.56; %H, 7.74; %N, 20.18; Found: %C, 60.30; %H, 7.72; %N, 20.1 1.

Provenance & Evidence