HCID 22645199, compound → HCID 22645134, compound

HRID 1837603Notes

Reaction equation

HRID 1837603 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[CH2:20][OH:21])[C:15]#[N:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[CH:20]=[O:21])[C:15]#[N:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 22645199HCID 22645199, compound

Product 1

HCID 22645134HCID 22645134, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

0.3 g (1.03 mmol) of 3-(2-(t-butoxycarbonylamino)ethoxy)-4-hydroxymethylbenzonitrile was dissolved in 3 ml of dichloromethane (dehydrated). 0.36 g (4.1 mmol) of activated manganese dioxide was added to the obtained solution in the presence of argon, and they were stirred at room temperature overnight. The reaction solution was filtered through Celite to obtain the title compound.

Workup

  1. filtrationThe reaction solution was filtered through Celite

Sources & evidence

ORD record
ord-d3e37a559c6148739b66ceeb7c5aadf6
Source dataset
uspto-grants-2004_08
Patent number
US06784191B2

Reaction notes

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