4-Methoxyphenol → HCID 22325249, compound

HRID 1837655Notes

Reaction equation

HRID 1837655 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH2:14]Cl>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([CH2:14][C:13]2[CH:16]=[CH:17][CH:18]=[C:11]([F:10])[CH:12]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 99743-Fluorobenzyl chloride

Product 1

HCID 22325249HCID 22325249, compound

Procedure

Alkylation of 4-methoxyphenol with 3-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-methoxy-2-(3′-fluorobenzyl)phenol. This material was converted to compound 71 and compound 72 by the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-1cada9f8ac094e0e98c2ada2369e4ad1
Source dataset
uspto-grants-2004_08
Patent number
US06784201B2

Reaction notes

Loading…