4-Methoxyphenol → HCID 22325222, compound

HRID 1837656Notes

Reaction equation

HRID 1837656 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13]Cl>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([CH2:13][C:12]2[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=2[F:10])[CH:4]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 9580Benzene, 1-(chloromethyl)-2-fluoro-

Product 1

HCID 22325222HCID 22325222, compound

Procedure

Alkylation of 4-methoxyphenol with 2-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-methoxy-2-(2′-fluorobenzyl)phenol. This material was converted to compound 73 and compound 74 by the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-c72f2480d0db41a1b3d1ad2c9e53ad8b
Source dataset
uspto-grants-2004_08
Patent number
US06784201B2

Reaction notes

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