反应详情

2.58 g of 5-bromo-2-methoxy-3-pyridinecarboxaldehyde was dissolved in 30 ml of dichloromethane, a mixture of 9 ml of trimethyl orthoformate and montmorillonite K-10 (3 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. After filtering the reaction solution, the filtrate was evaporated. To the residue was added ethyl acetate, followed by filtering through alumina. The filtrate was evaporated, to give 3.09 g of the title compound as a yellow oil.

1. additionwas added
2. filtrationAfter filtering the reaction solution
3. customthe filtrate was evaporated
4. additionTo the residue was added ethyl acetate
5. filtrationby filtering through alumina
6. customThe filtrate was evaporated