Vinyl chloroformate → HCID 22678472, compound

Participants

Reaction Steps

2.848 g of 1-benzyl-4-[(E)-2-[(2-cyclohexylmethyloxy)phenyl]-1-ethenyl]piperidine was dissolved in 15 ml of 1,2-dichloroethane, 0.93 ml of vinyl chloroformate was added thereto, and the mixture was stirred at room temperature for 50 minutes and heated under reflux for one hour. The solvent was evaporated, and the crude product was purified by silica gel column chromatography (n-hexane:ethyl acetate=50:1), to give 2.026 g of the title compound as a colorless oil.

Provenance & Evidence