反应详情

904 mg of 1-(vinyloxycarbonyl)-4-[(E)-2-(2-fluorophenyl)-1-ethenyl]piperidine was suspended in 5 ml of a 10% hydrogen chloride-methanol solution. After stirring for 15 minutes at room temperature, the mixture was heated at 70° C. for one hour. The solvent was evaporated, and water and ethyl acetate were added to the residue, to separate the aqueous layer. The aqueous layer was basified with a diluted ammonia, and extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, to give 660 mg of the title compound as a colorless oil.

1. temperaturethe mixture was heated at 70° C. for one hour
2. customThe solvent was evaporated
3. additionwater and ethyl acetate were added to the residue
4. customto separate the aqueous layer
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with water and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was evaporated