1-[(2-Methoxy-3-pyridyl)methyl]-4-[2-[3-(methylsulfonyl)-2-thienyl]-1-ethynyl]piperidine → HCID 22678292, compound

HRID 1837729Notes

Reaction equation

HRID 1837729 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([C:16]#[C:17][C:18]3[S:19][CH:20]=[CH:21][C:22]=3[S:23]([CH3:26])(=[O:25])=[O:24])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.[H][H]>C(O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][CH2:17][C:18]3[S:19][CH:20]=[CH:21][C:22]=3[S:23]([CH3:26])(=[O:25])=[O:24])[CH2:14][CH2:15]2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 2

HCID 226783641-[(2-Methoxy-3-pyridyl)methyl]-4-[2-[3-(methylsulfonyl)-2-thienyl]-1-ethynyl]piperidineHCID 178418361HCID 178418361, compound

Product 1

HCID 22678292HCID 22678292, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

450 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-[3-(methylsulfonyl)-2-thienyl]-1-ethynyl]piperidine and 250 mg of 10% palladium-carbon powder (water-containing product) were suspended in 10 ml of ethanol. After replacing the atmosphere of a container with hydrogen, the mixture was stirred at room temperature under normal pressure for 8 hours. The reaction solution was filtered, and the filtrate was evaporated, to give the title compound as a yellow oil (quantitatively).

Workup

  1. filtrationThe reaction solution was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-5a5de6fc6a0445869e967aa2292bc4cd
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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