2-(Tributylstannyl)-1,3-thiazole → HCID 22678636, compound

Participants

Reaction Steps

150 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-[2-[((trifluoromethyl)sulfonyl]oxy]-3-pyridyl]ethyl]piperidine, 180 mg of 2-(tributylstannyl)thiazole and 20 mg of tetrakis(triphenylphosphine)palladium were suspended in 4 ml of toluene, and the mixture was heated under reflux for 2 hours under nitrogen flow. The solvent was evaporated, and the residue was purified by NH form silica gel column chromatography (ethyl acetate:hexane=1:4), to give 39 mg of the title compound as a colorless oil.

Provenance & Evidence