Ethyl Acetate → HCID 22678378, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-(2-oxo-1,2-dihydro-3-pyridinyl)ethyl]piperidine obtained in Example 47,95 mg of γ-bromobutyronitrile and 169 mg of potassium carbonate were suspended in 5 ml of N,N-dimethylformamide, and the mixture was stirred at 60° C. for 4 hours. Ethyl acetate was added thereto, the resulting salt was filtered off, and the solvent was evaporated. The crude product was purified by NH form silica gel column chromatography (ethyl acetate:hexane=1:4), to give 77 mg of the title compound as a colorless oil.

Provenance & Evidence