Ammonium Chloride → HCID 22678342, compound

Participants

Reaction Conditions

Reaction Steps

0.50 g of N1-methoxy,N1-ethyl-2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetamide obtained in Example 55 was dissolved in 3 ml of tetrahydrofuran and 1.8 ml of a 1.0M (2-thienyl)-lithium in tetrahydrofuran was added dropwise thereinto at −78° C. After completion of the dropwise addition, the mixture was further stirred at −78° C. for 1 hour. An aqueous saturated ammonium chloride was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified by silica gel column chromatography (ethyl acetate), to give 0.22 g of the title compound as a pale yellow oil. The NMR spectrum data of the title compound were agreed with those of Example 54.

Provenance & Evidence