2-(Tributylstannyl)-1,3-thiazole → HCID 22678387, compound

Participants

Reaction Steps

300 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-(3-bromo-2-thienyl)-2-oxoethyl]piperidine obtained in Example 73, 438 mg of 2-(tributylstannyl)thiazole and 42 mg of tetrakis(triphenylphosphine)palladium were suspended in 4 ml of toluene, and the mixture was heated under reflux for 2 hours under nitrogen flow. The solvent was evaporated, and the residue was purified by silica gel column chromatography (ethyl acetate), to give 300 mg of the title compound as a colorless oil.

Provenance & Evidence