Water → HCID 22678577, compound

Participants

Reaction Conditions

Reaction Steps

168 mg of 1-[(2-oxo-1,2-dihydro-3-pyridinyl)methyl]-4-(2-(2-chloro-3-pyridyl)ethyl]piperidine obtained in Example 117 and 354 mg of sodium thiomethoxide were suspended in 5 ml of 1-methyl-2-pyrrolidinone, and the mixture was stirred at 150° C. for 2 hours. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified by NH form silica gel column chromatography (methanol:ethyl acetate=1:19), to give 20 mg of the title compound as colorless crystals.

Provenance & Evidence