Water → HCID 22678386, compound

Participants

Reaction Conditions

Reaction Steps

183 mg of 1-[(2-oxo-1,2-dihydro-3-pyridinyl)methyl]-4-[2-(2-chloro-3-pyridyl)ethyl]piperidine obtained in Example 117 and 226 mg of oil-dispersed 60% sodium hydride were suspended in 3 ml of 2-methoxyethanol, and the mixture was stirred at 150° C. for 2 hours. Water was added to the reaction solution, and the mixture was extracted with dichloromethane. The organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified by NH form silica gel column chromatography (methanol:ethyl acetate=1:19), to give 135 mg of the title compound as colorless crystals.

Provenance & Evidence