Hydrogen chloride-ethyl acetate → HCID 22678729, compound

HRID 1837749Notes

Reaction equation

HRID 1837749 reaction equation
C[O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH:17]([C:26]#[N:27])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.C(OC(=O)C)C.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[O:2]=[C:3]1[C:8]([CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][CH:17]([C:26]#[N:27])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])[CH2:14][CH2:15]2)=[CH:7][CH:6]=[CH:5][NH:4]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22678339HCID 22678339, compound

Product 1

HCID 22678729HCID 22678729, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (2 ml) was dissolved 191 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-cyano-2-(2-methoxyphenyl)ethyl]piperidine obtained in Example 86. To the mixture was added 0.3 ml of a 4N hydrogen chloride ethyl acetate solution, followed by heating under reflux for 2 hours. The solvent was evaporated, to give 199 mg of the title compound as colorless crystals.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 2 hours
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-df83112badc7457cbb26d99f6d9e5369
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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