Water → HCID 22678563, compound

HRID 1837750Notes

Reaction equation

HRID 1837750 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]4[O:23][CH2:24][O:25][C:18]=34)[CH2:11][CH2:10]2)[CH:5]=[CH:4][CH:3]=1.[OH2:26].[CH3:27]O.C[O-].[Na+]>>[CH3:27][O:26][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]4[O:23][CH2:24][O:25][C:18]=34)[CH2:11][CH2:10]2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 962WaterHCID 22678575HCID 22678575, compoundHCID 23694274Sodium methanolate methanol

Product 1

HCID 22678563HCID 22678563, compound

Procedure

In a 28% sodium methoxide methanol solution (2 ml) was dissolved 218 mg of 1-[(6-bromo-2-pyridyl)methyl]-4-(2,3-methylenedioxyphenethyl)piperidine obtained in Referential Example 19, followed by heating under reflux for 1 hour. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 144 mg of the title compound as a colorless oil.

Workup

  1. customobtained in Referential Example 19
  2. temperatureby heating
  3. temperatureunder reflux for 1 hour
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customthe solvent was evaporated

Sources & evidence

ORD record
ord-b3f644f2e55c4221b2f299e8c9ec14ba
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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