反应详情

370 mg of N1-(3-fluorobenzyl)-2-[1-[2-(2-methoxy-3-pyridyl)ethyl]-2-piperidyl]acetamide obtained in Example 177, 0.44 ml of thionyl chloride and 5 ml of ethanol were stirred at 100° C. for 2 hours. The solvent was evaporated, and to the residue was added an aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate, and dried over sodium sulfate. Then the drying agent was filtered off, and the solvent was evaporated, to give 330 mg of white crystals.

1. customThe solvent was evaporated
2. additionto the residue was added an aqueous sodium bicarbonate
3. extractionThe mixture was extracted with ethyl acetate
4. dry with materialdried over sodium sulfate
5. filtrationThen the drying agent was filtered off
6. customthe solvent was evaporated