HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[(2-Methoxy-3-pyridinyl)methyl]-4-[(2-methoxyphenoxy)methyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Chloromethyl)-2-methoxypyridine | HCID 14932945 | — |
| Reactant | 4-[(2-Methoxyphenoxy)methyl]piperidine | HCID 22248030 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[(2-Methoxy-3-pyridinyl)methyl]-4-[(2-methoxyphenoxy)methyl]piperidine | HCID 22678662 | 82.6% |
Reaction Steps
200 mg of 2-methoxy-3-(chloromethyl)pyridine, 380 mg of 4-[(2-methoxyphenoxy)methyl]piperidine and 235 mg of potassium carbonate were added in 10 ml of acetonitrile, and the mixture were stirred at room temperature for 3 hours 15 minutes. After filtering the reaction solution, the solvent was evaporated, and the crude product was purified by silica gel column chromatography (hexane:ethyl acetate=3:2), to give 359 mg of the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06784192B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-79159ad056fd416ea496c4c8c71d6e3b |
| Source note | uspto-grants-2004_08 |