Acetonitrile → HCID 22678365, compound

Participants

Reaction Steps

To acetonitrile (10 ml) were added 500 mg of 2-methoxy-3-(chloromethyl)pyridine, 1.04 g of 4-[(E)-2-[(2-cyclohexylmethyloxy)phenyl]-1-ethenyl]piperidine and 531 mg of potassium carbonate, followed by stirring at room temperature overnight. Ethyl acetate was added to the reaction solution, and the mixture was filtered through alumina-silica gel. Then, the solvent was evaporated, and the crude product was purified by silica gel column chromatography (hexane:ethyl acetate=8:1), to give 961 mg of the title compound as a pale yellow oil.

Provenance & Evidence