Sodium Bicarbonate → HCID 22678688, compound

Participants

Reaction Steps

In ethanol (4 ml) was dissolved 226 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-[2-(cyclohexylmethyloxy)phenyl]ethyl]piperidine. To the mixture was added 1 ml of a 4N-hydrogen chloride-ethyl acetate solution, followed by heating under reflux for 1.5 hours. An aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated. The resulting oil was dissolved in ethanol, 49 mg of oxalic acid and ethyl acetate were added thereto, and then the resulting precipitates were collected by filtration, to give 229 mg of the title compound as a white powder.

Provenance & Evidence