Hydrogen chloride-ethyl acetate → HCID 22678400, compound

HRID 1837769Notes

Reaction equation

HRID 1837769 reaction equation
C[O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.C(OCC)(=O)C.[ClH:38]>C(O)C>[ClH:38].[ClH:38].[O:2]=[C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][NH:4]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22678436HCID 22678436, compound

Product 1

HCID 22678400HCID 22678400, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (8 ml) was dissolved 294 mg of 1-[(2-methoxy-3-pyridinyl)methyl]-4-[2-[2-(benzylamino)phenyl]ethyl]piperidine. To the mixture was added 3 ml of a 4N-hydrogen chloride-ethyl acetate solution, followed by heating under reflux for 3 hours. After cooling as it was, the resulting precipitates were collected by filtration and recrystallized from ethanol, to give 273 mg of the title compound as a white powder.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling as it
  4. customthe resulting precipitates
  5. filtrationwere collected by filtration
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-839413de8c534cbab35fb768fdad97df
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

Loading…