Sodium Carbonate → HCID 22678572, compound

HRID 1837770Notes

Reaction equation

HRID 1837770 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH2:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:16][CH2:15]2)[C:8]([O:11]C)=[N:9][CH:10]=1)(=[O:4])=[O:3].S(Cl)(Cl)=O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH2:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:16][CH2:15]2)[C:8](=[O:11])[NH:9][CH:10]=1)(=[O:3])=[O:4]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 22678395HCID 22678395, compound

Product 1

HCID 22678572HCID 22678572, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (10 ml) was dissolved 138 mg of 1-[(5-(methylsulfonyl)-2-methoxy-3-pyridinyl)methyl]-4-[2-[2-(cyclohexylmethyloxy)phenyl]ethyl]piperidine. To the mixture was added 1 ml of thionyl chloride, followed by heating under reflux for 2.5 hours. An aqueous sodium carbonate aqueous solution was added to the reaction solution, and the resulting precipitates were collected by filtration, to give 127 mg of the title compound as a white powder.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 2.5 hours
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-d4ea9fdfc0fd4e9fb3e7b17bc150092e
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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