Sodium Carbonate → 1-[(2-Oxo-1,2-dihydro-3-pyridinyl)methyl]-4-[(E)-2-[(2-cyclohexylmethyloxy)phenyl]-1-ethenyl]piperidine Oxalate

Participants

Reaction Steps

In ethanol (12 ml) was dissolved 221 mg of 1-[(5-chloro-2-methoxy-3-pyridinyl)methyl]-4-[(E)-2-(2-fluorophenyl)-1-ethenyl]piperidine. To the mixture was added 12 ml of a 4N-hydrogen chloride-ethyl acetate solution, followed by heating under reflux for 11 hours. An aqueous sodium carbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and then the solvent was evaporated. Ether was added to the obtained oil, to crystallize. The title compound (176 mg) was obtained as a light pink powder.

Provenance & Evidence