Ethanolamine → N-(2-Hydroxyethyl)phthalimide

HRID 1837798Notes

Reaction equation

HRID 1837798 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[OH:13][CH2:12][CH2:14][N:15]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 6811Phthalic Anhydride

Product 1

HCID 77499N-(2-Hydroxyethyl)phthalimide

Procedure

Phthalic anhydride (100 g, 0.67M) was condensed with monoethanol amine (41.2 g, 0.91 M) at 160-178° C. for 4 hours. The reaction mass was quenched in hot water at 95° C., cooled and filtered and washed with water twice and dried at 90-95° C. for 12 hours. Yield 118 g.

Workup

  1. customThe reaction mass was quenched in hot water at 95° C.
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water twice
  5. customdried at 90-95° C. for 12 hours

Sources & evidence

ORD record
ord-8811deeebe7c48d59451dc836ff1a1e1
Source dataset
uspto-grants-2004_08
Patent number
US06784297B2

Reaction notes

Loading…