Methyl 6-aminonicotinate → HCID 10277754, compound

HRID 1837821Notes

Reaction equation

HRID 1837821 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[CH:12]1([CH2:18][C@H:19]([N:23]2[C:27](=[O:28])[C@H:26]([CH2:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[NH:25][C:24]2=[O:36])[C:20](O)=[O:21])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:21])[C@@H:19]([N:23]2[C:27](=[O:28])[C@H:26]([CH2:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[NH:25][C:24]2=[O:36])[CH2:18][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 737487Methyl 6-aminonicotinateHCID 67483652HCID 67483652, compound

Product 1

HCID 10277754HCID 10277754, compound

Procedure

By using the conditions described in Step (iv) of Example 17, methyl 6-aminonicotinate was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd for C26H36N4O5 (M+) 485.2764, found 485.2768.

Sources & evidence

ORD record
ord-12800bb3114f4edd81974727e177852e
Source dataset
uspto-grants-2004_08
Patent number
US06784298B2

Reaction notes

Loading…