2-Aminopyridine → HCID 10224339, compound

HRID 1837823Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:8]1([CH2:14][C@H:15]([N:19]2[C:23](=[O:24])[C@H:22]([CH2:25][CH:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[NH:21][C:20]2=[O:32])[C:16](O)=[O:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([CH2:14][C@H:15]([N:19]2[C:23](=[O:24])[C@H:22]([CH2:25][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[NH:21][C:20]2=[O:32])[C:16]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)=[O:17])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

Reactant 2

HCID 104392-Aminopyridine

HCID 67483652HCID 67483652, compound

Product 1

HCID 10224339HCID 10224339, compound

Procedure

By using the conditions described in Step (iv) of Example 17, 2-aminopyridine was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd for C24H34N4O3 (M+) 427.2709, found 427.2706.

Sources & evidence

ORD record: ord-eddcd4d64ca843c6a0e4167aad2ca0f0
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06784298B2

Reaction notes

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