HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3R)-(-)-3-(1-Methyl-1H-indol-3-yl)butyraldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Methylindole | HCID 11781 | — |
| Reactant | Crotonaldehyde | HCID 447466 | — |
| Reactant | 5-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone, (2S,5S)- | HCID 10309834 | — |
| Product | (3R)-(-)-3-(1-Methyl-1H-indol-3-yl)butyraldehyde | HCID 9899133 | — |
Reaction Steps
This example describes the alkylation of 1-methyl-1H-indole with (E)-crotonaldehyde, catalyzed by the trifluoroacetic acid salt of (1), to provide (R)-3-(1-methyl-1H-indol-3-yl)-butanal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06784323B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-b5aa7e2cdb164ca98980660796a5ba7a |
| Source note | uspto-grants-2004_08 |