反应详情

A solution of the allylic alcohol 22-2 (1.2 g, 6.1 mmol) in triethyl orthoacetate (50 mL) was treated with propionic acid (0.022 mL, 0.31 mmol) and refluxed for 2 h. The cooled mixture was treated with a solution of 1:1 sat. brine/1N HCl (150 mL), then extracted with CH2Cl2 (3×125 mL). The pooled organic extracts were washed with sat. NaHCO3, dried, filtered and evaporated. Chromatography on silica gel (EtOAc) afforded 22-3 as a yellow glass.

1. temperaturerefluxed for 2 h
2. extractionextracted with CH2Cl2 (3×125 mL)
3. washThe pooled organic extracts were washed with sat. NaHCO3
4. customdried
5. filtrationfiltered
6. customevaporated