3-Amino-2-chlorobenzoic acid → HCID 9917165, compound

Participants

Reaction Steps

DPP-Cl(68 μl) and TEA(50 μl) were added to a solution of 3-amino-2-chlorobenzoic acid (56 mg) in EtOAc (2 ml), and the mixture was stirred for one hour. After the addition of the compound obtained in Step 2 of Example 1 (141 mg) and TEA (50 μl), the mixture was stirred overnight. The reaction mixture was washed with 5% Na2CO3 (×2), 1N HCl, and 5% NaCl, dried over MgSO4. After filtration and concentration, the residue was purified by silica gel column chromatography (CH2Cl2—MeOH), and reprecipitated from a mixture of CH2Cl2 and n-hexane to obtain the title compound (153 mg, 81%).

Provenance & Evidence