Oxalyl chloride → 1H-indole-2-carbonyl Chloride

Participants

Reaction Conditions

Reaction Steps

To a solution of indole-2-carboxylic acid (960 mg, 6.0 mmol), 10 mL CH2Cl2 and 2 drops DMF under argon at 0° C., was added oxalyl chloride (2.68 mL, 24.0 mmol) dropwise. The reaction was stirred at 23° C. for 3.5 hours and then concentrated in vacuo to yield a yellow oil which was taken on to the next step without further purification.

Provenance & Evidence