1-Phenylpiperazine → HCID 135617192, compound

Participants

Reaction Steps

In analogy to the procedure described in example 1, the 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one (as prepared in Eur. Pat. Appl. EP 1 074 549 A2) was treated with the 1-phenylpiperazine in N,N-dimethylformamide in the presence of potassium carbonate at room temperature to yield the 2-methyl-5-nitro-6-(4-phenyl-piperazin-1-yl)-3H-pyrimidin-4-one as yellow solid; m.p.>250° C. (decomposition); MS: [M−H]−=314.

Provenance & Evidence