1-(4-Fluorophenyl)piperazine → 4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	1-(4-Fluorophenyl)piperazine	HCID 75260	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-Chloro-2,6-bis[(2-hydroxyethyl)amino]pyrimidine-5-carbonitrile	HCID 18753217	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile	HCID 18753236	—

Reaction Steps

In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile was treated with the 1-(4-fluorophenyl)-piperazine in dioxane in the presence of N-ethyl-diisopropylamine at 60° C. to yield 4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as a white lyophilisate; MS: [M+H]+=402.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06673795B2
Source dataset	uspto-grants-2004_01
ORD ID	ord-386a10fe3eac4ae18f96f8b8689c1372
Source note	uspto-grants-2004_01