HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-[4-(2-Cyano-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(2-Cyanophenyl)piperazine | HCID 2735875 | — |
| Reactant | 4-Chloro-2,6-bis[(2-hydroxyethyl)amino]pyrimidine-5-carbonitrile | HCID 18753217 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[4-(2-Cyano-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile | HCID 18753294 | — |
Reaction Steps
In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile was treated with 1-(2-cyanophenyl)-piperazine in dioxane in the presence of N-ethyl-diisopropylamine at 50° C. to yield 4-[4-(2-cyano-phenyl)-piperazin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as an amorphous, light brown solid; MS: [M]+=408.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673795B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-f74d11402a3f4ababbe6fa80c227f018 |
| Source note | uspto-grants-2004_01 |