1-(4-Fluorophenyl)piperazine → HCID 18753271, compound

Participants

Reaction Steps

In analogy to the procedure described in example 20b, 4,6-dichloro-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile (example 41a) was treated with 4-(4-fluoro-phenyl)-piperazine in dioxane in the presence of N-ethyl-diisopropylamine at room temperature to yield 4-chloro-6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as an amorphous, white solid; MS: [M+H]+=377.

Provenance & Evidence