HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 18753286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 18753232 | HCID 18753232 | — |
| Reactant | 4-(4-Fluoro-phenyl)-piperidine hydrochloride | HCID 21898168 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 18753286 | HCID 18753286 | — |
Reaction Steps
In analogy to the procedure described in example 20b, 4,6-dichloro-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile (example 41a) was treated with 4-(4-fluoro-phenyl)-piperidine hydrochloride in dioxane in the presence of N-ethyl-diisopropyl-amine at room temperature to yield 4-chloro-6-[4-(4-fluoro-phenyl)-piperidin-1-yl]-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as a white lyophilisate; MS: [M+H]+=376.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673795B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-c58e614a699e493f8f2837cdab608eba |
| Source note | uspto-grants-2004_01 |