HCID 2757550, compound → HCID 2729109, compound

HRID 1838218Notes

Reaction equation

HRID 1838218 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[CH:9]([OH:20])[C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)=[O:11].ClC1C=C(F)C=CC=1C(O)C(O)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([OH:20])[C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=1)=[O:11]

Participants

3

Reactant 2

HCID 2757550HCID 2757550, compoundHCID 18752937HCID 18752937, compound

Product 1

HCID 2729109HCID 2729109, compound

Procedure

In the same way, (2-chloro-4-fluorophenyl)-N-(4-chlorophenyl)hydroxyacetamide, compound VII.3, is prepared from (2-chloro-4-fluorophenyl)hydroxyacetic acid (synthesized according to J. Med. Chem., 1987, 30 (8), 1447, from 2-chloro-4-fluorobenzaldehyde and bromoform); M.p.=136° C.

Sources & evidence

ORD record
ord-7c9f8c58bdb24424999b4497386b6df4
Source dataset
uspto-grants-2004_01
Patent number
US06673790B1

Reaction notes

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