4-Fluorophenyl isocyanate → HCID 18753334, compound

HRID 1838236Notes

Reaction equation

HRID 1838236 reaction equation
[NH2:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=1>ClCCl>[C:9]([C:8]1[CH:11]=[CH:12][C:5]([NH:4][CH2:3][C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=2)=[O:28])([CH3:18])[CH3:17])=[CH:6][C:7]=1[C:13]([F:14])([F:15])[F:16])#[N:10]

Participants

4

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 18753365HCID 18753365, compound

Product 1

HCID 18753334HCID 18753334, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(2-Amino-2-methylpropylamino)-2-trifluoromethylbenzonitrile was dissolved in 60 ml of dichloromethane, 0.49 ml of 4-fluorophenyl isocyanate was added dropwise to the solution and then the mixture was stirred at room temperature for 1 hour. The thus precipitated crystals were collected by filtration, washed with dichloromethane and then dried to obtain 1.30 g of the title compound.

Workup

  1. filtrationThe thus precipitated crystals were collected by filtration
  2. washwashed with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-b3e6ccb4ce864f058975992945ca8c13
Source dataset
uspto-grants-2004_01
Patent number
US06673799B1

Reaction notes

Loading…