4-Fluoro-2-(trifluoromethyl)benzonitrile → (2S,5R)-4-(4-Benzyl-2,5-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile

Participants

Reaction Conditions

Reaction Steps

A 15 ml portion of pyridine solution containing 0.63 g of (2R,5S)-1-benzyl-2,5-dimethylpiperazine was mixed with 0.7 g of 4-fluoro-2-trifluoromethylbenzonitrile and stirred at 90° C. for 2 days. The reaction mixture was concentrated and the residue was purified by a silica gel column chromatography to obtain the title compound from n-hexane-ethyl acetate (9:2, v/v) as a white solid.

Provenance & Evidence