2-Methoxy-5-pyridinecarbonitrile → (6-Methoxypyridin-3-yl)methanamine

Participants

Reaction Steps

A 1.00 g portion of 5-cyano-2-methoxypyridine was dissolved in 30 ml of ethanol and 10 ml of 28% aqueous ammonia, mixed with 1 g of Raney nickel and then stirred at room temperature for 4 hours at atmospheric pressure in a stream of hydrogen. After filtration through celite, the solvent was evaporated to obtain 962 mg of the title compound.

Provenance & Evidence