HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(Methylamino)pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-(Methylamino)pyridine-3-carboxylic acid | HCID 22271415 | — |
Reaction Steps
A 20 ml pyridine solution of 10 g of 6-chloronicotinic acid and 27 ml of 40% methylamine aqueous solution was heated at 150° C. for 24 hours in a sealed tube. After spontaneous cooling to room temperature, this was mixed with water and adjusted to pH 3 with 1 N aqueous hydrochloric acid. The precipitated crystals were collected by filtration to obtain 5.82 g of the title compound as grayish white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673799B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-f62f888c96734137889954b0f2443e6b |
| Source note | uspto-grants-2004_01 |