反应详情

温度

50 °C

A 1.0 g portion of 1-[2-(4-cyano-3-trifluoromethylanilino)-1,1-dimethylethyl]-3-(4-fluorophenyl)urea synthesized in Reference Example 9-1 was dissolved in 10 ml of acetic acid, and the solution was mixed with 0.4 ml of formalin and heated at 50° C. for 2 hours. The solvent was evaporated, the resulting residue was purified by a silica gel column chromatography, and the compound obtained from chloroform-methanol (30:1, v/v) eluate was washed with diisopropyl ether to obtain 751 mg of the title compound.

1. customThe solvent was evaporated
2. customthe resulting residue was purified by a silica gel column chromatography
3. customthe compound obtained from chloroform-methanol (30:1
4. washv/v) eluate was washed with diisopropyl ether