Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzonitrile | HCID 605085 | — |
| Reactant | 1-Cbz-3-Methylpiperazine | HCID 10421542 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 9931002 | HCID 9931002 | — |
Reaction Steps
A 1.01 g portion of benzyl 3-methylpiperazine-1-carboxylate synthesized in Reference Example 10, 814 mg of 4-fluoro-2-trifluoromethylbenzonitrile and 2.38 g of potassium carbonate were added to 20 ml of DMF and stirred at 100° C. for 20 hours. This was mixed with water, extracted with ethyl acetate and dried, and then the solvent was evaporated. The resulting residue was purified by a silica gel column chromatography to obtain 440 mg of the title compound from ethyl acetate-hexane (3:1, v/v) eluate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06673799B1 |
|---|
| Source dataset | uspto-grants-2004_01 |
|---|
| ORD ID | ord-bf903aea420249fbb9ed052228d24de2 |
|---|
| Source note | uspto-grants-2004_01 |
|---|
