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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1838274Generated: November 1, 2026

Benzhydrylpiperazine → HCID 10227913, compound

https://huagongshe.com/reaction/1838274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzhydrylpiperazineHCID 70048—
ReactantSodium triacetoxyborohydrideHCID 5049666—
ReactantHCID 18753383HCID 18753383—
SolventDichloromethaneHCID 6344—
ProductHCID 10227913HCID 1022791353.4%

Reaction Steps

3-[3-(3-nitrophenyl)-4,5-Dihydroisoxazol-5-yl]propanal (21.9 mg, 0.088 mmol), 1-(diphenylmethyl)piperazine (20.3 mg, 0.080 mmol), molecular sieves (5 beads), and NaBH(OAc)3 (51.1 mg, 0.241 mmol) were reacted in 3 mL of methylene chloride for about 12 hr. With the following processes the same as in Example 1, 20.7 mg (48.4%) of the target compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06673800B2
Source datasetuspto-grants-2004_01
ORD IDord-d38e7a4d5c15406eb683d3d2b70a966b
Source noteuspto-grants-2004_01