1-(Bis(4-fluorophenyl)methyl)piperazine → HCID 10118829, compound

Participants

Reaction Steps

3-[3-(3-Nitrophenyl)-4,5-dihydroisoxazol-5-yl]propanal (19.3 mg, 0.077 mmol), 1-[bis(4-fluorophenyl)methyl]piperazine (20.4 mg, 0.070 mmol), molecular sieve (5 beads) and NaBH(OAc)3 (45.0 mg, 0.212 mmol) were reacted in 3 mL of methylene chloride for about 12 hr. With the following processes the same as in Example 1, 23.8 mg (64.7%) of the target compound was obtained.

Provenance & Evidence