反应详情

A mixture of 1-benzenesulfonyl-5-methylthioindole-2-carboxylic acid (3.5 g), sulfuric acid (10 ml) and methanol (10 ml) was heated under reflux for 12 hours. The reaction mixture was poured into ice-water and the mixture was extracted with dichloromethane. The organic layer was washed with water, dried over sodium sulfate and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (dichloromethane) to obtain 3.4 g of the desired product as a white crystal.

1. temperaturewas heated
2. temperatureunder reflux for 12 hours
3. extractionthe mixture was extracted with dichloromethane
4. washThe organic layer was washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure