HCID 22504373, compound → HCID 22504424, compound

HRID 1838398Notes

Reaction equation

HRID 1838398 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[C:5]2[CH:11]=[C:10]([CH2:12][OH:13])[NH:9][C:6]2=[N:7][CH:8]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[CH3:1][S:2][C:3]1[N:4]=[C:5]2[CH:11]=[C:10]([CH:12]=[O:13])[NH:9][C:6]2=[N:7][CH:8]=1

Participants

4

Reactant 1

HCID 22504373HCID 22504373, compound

Product 1

HCID 22504424HCID 22504424, compoundYield 49.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Conditions

Temperature
22.5 °C

Procedure

To a solution of the compound obtained in Example 34 (4) (123 mg) in acetone (40 ml), manganese dioxide (1.86 g) was added and the mixture was stirred at 15 to 30° C. for 1 hour. The reaction solution was filtered through Celite and concentrated under reduced pressure to obtain 60 mg (49.3%) of the desired product as a yellow powder.

Workup

  1. filtrationThe reaction solution was filtered through Celite
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7d7ee00b065a4ab48e95bbc345ceba61
Source dataset
uspto-grants-2004_01
Patent number
US06673797B1

Reaction notes

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