Methyl iodide → HCID 18753515, compound

Participants

Reaction Steps

Methyl iodide (0.83 g, 5.8 mmol) and potassium carbonate (5.34 g, 38.4 mmol) were added to a solution of (±)-N-(4-phenoxybenzenesulfonyl)-2-(2-phthalimidoethyl)glycine allyl ester (2.00 g, 3.8 mmol), the product of (2) above, in N,N-dimethylformamide (20 ml). This mixture was stirred at room temperature for 1 hour. The insoluble material was removed by filtration. The filtrate was extracted with ethyl acetate and the organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=3/1 as the eluant to afford the desired compound (1.90 g, yield 93%) as a colorless oil.

Provenance & Evidence