Hydrochloric Acid → HCID 9827063, compound

Participants

Reaction Steps

Water (1.75 ml), tetrakis(triphenylphosphine)palldium(0) (8.2 mg. 0.007 mmol) and pyrrolidine (0.45 ml, 5.3 mmol) were successively added to a solution of (±)-N-methyl-N-(4-phenoxybenzenesulfonyl)-2-(2-phthalimidoethyl)glycine allyl ester (1.88 g, 3.5 mmol), the product of (3) above, in dioxane (33 ml) and the mixture was stirred at room temperature for 4 hours. The reaction mixture was acidified with hydrochloric acid (1N) and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crystalline residue was washed with diethyl ether to give the title compound (1.64 g, yield 94%) as a white powder.

Provenance & Evidence