HCID 6463212, compound → HCID 18753534, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (±)-2-[2-(1-benzyloxymethylquinazolin-2,4-dione-3-yl)ethyl)]-N-methyl-N-(4-phenoxybenzenesulfonyl)glycine (1.89 g, 3.0 mmol), the product of (4) above, in tetrahydrofuran (30 ml) was added to a suspension of palladium hydroxide (20%, containing 50% water, 0.42 g, 0.30 mmol) in methanol (30 ml). The mixture was stirred vigorously under a hydrogen atmosphere at 50° C. for 2 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to afford (±)-2-[2-(1-hydroxymethylquinazolin-2,4-dione-3-yl)ethyl]-N-methyl-N-(4-phenoxybenzenesulfonyl)glycine (1.62 g) as a colorless amorphous solid.

Provenance & Evidence